법랑모세포종에서 Receptor Activatorof Nuclear Factor-ĸB Ligand(RANKL)와 Osteoprotegerin(OPG) 발현에 관한 연구
Identification of receptor activator of nuclear factor-ĸB ligand(RANKL) and osteoprotegerin(OPG) in ameloblastoma
하우연, 황대석, 김용덕, 신상훈, 김욱규, 김종렬, 정인교,
소속 상세정보
하우연 ( Ha Woo-Hun ) - 부산대학교 치과대학 구강악안면외과학교실
황대석 ( Hwang Dae-Seok ) - 부산대학교 치과대학 구강안면외과학교실
김용덕 ( Kim Yong-Deok ) - 부산대학교 치과대학 구강안면외과학교실
신상훈 ( Shin Sang-Hun ) - 부산대학교 치과대학 구강안면외과학교실
김욱규 ( Kim Uk-Kyu ) - 부산대학교 치과대학 구강안면외과학교실
김종렬 ( Kim Jong-Ryoul ) - 부산대학교 치과대학 구강안면외과학교실
정인교 ( Jung In-Kyo ) - 부산대학교 치과대학 구강안면외과학교실
KMID : 0355620070330020094
Abstract
The ameloblastoma is a common odontogenic tumor of the jaw bone and represents approximately 1% of tumor in the jaw. However, it might be able to infiltrate into the adjacent tissue, causing bony destruction and high recurrent rate. In this study, expression of RANKL and OPG in ameloblastoma in relation to age and gender of patient and recurrence, location of the lesion were examined through immunohistochemisry study. The RANKL and OPG antibody staining were used. The obtained result were as follow. 1. Positive immunoreactivity to RANKL/OPG in all specimens was found. 2. In recurrenc, location of ameloblastoma and age, gender of patients using immunohistochemical expression of RANKL. There was not significant difference. 3. In recurrence, location of ameloblastoma and age, gender of patients using immunohistochemical expression of OPG. There was not significant difference. In summary, it is suggested that activation of osteoclasts by RANKL is an important mechanism by which ameloblastomas cause bone destruction.
키워드
AmeloblastomaRANKL;OPG
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